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Image Search Results
Journal: International Journal of Molecular Sciences
Article Title: Modeling Neuroimmune Interactions in Human Subjects and Animal Models to Predict Subtype-Specific Multidrug Treatments for Gulf War Illness
doi: 10.3390/ijms22168546
Figure Lengend Snippet: Human blood cytokine levels in PTSD-based GWI subtypes as compared to HC at rest (T0) and peak exercise during a maximal graded exercise challenge (T1). Individual cytokine values are normalized to the HC values, and bars represent the mean ratios ± SEM for each cytokine. Significance was set at * p < 0.05, ** p < 0.01, and *** p < 0.001 as compared to HC. The false discovery rate, as calculated via Storey et al. , was < 0.1 for all significant measures. Values are found in .
Article Snippet: Briefly, serum samples were analyzed using
Techniques:
Journal: International Journal of Molecular Sciences
Article Title: Modeling Neuroimmune Interactions in Human Subjects and Animal Models to Predict Subtype-Specific Multidrug Treatments for Gulf War Illness
doi: 10.3390/ijms22168546
Figure Lengend Snippet: Cytokine expression in a long-term mouse model of Gulf War Illness. ( A ) Graphical representation of the animal dosing paradigm. Mice were exposed to corticosterone (CORT; 200 mg/L in 0.6% ethanol) for 4 days at a time every other week for a total of 11 weeks. DFP (4 mg/kg, i.p.) was given on Day 5 and the LPS challenge (0.5 mg/kg, s.c.) was given after the final week of CORT. ( B ) Individual serum cytokine values normalized to the water (H2O), saline solution (SL), and SL condition values. Bars represent the mean ratios ± SEM for each cytokine. Significance was set at p < 0.05 compared to H2O SL SL (*), and within challenge groups (&: H2O DFP SL vs. H2O DFP LPS; and #: CORT DFP SL vs. CORT DFP LPS). The false discovery rate, as calculated via Storey et al. , was <0.1 for all significant measures. ( C ) Cytokine mRNA was measured in the frontal cortex ( n = 2–5/group) by qRT-PCR 6 h following exposure to LPS. Bars represent the mean ± SEM. Significance was set at p ≤ 0.05 for comparisons within challenge group (*: DFP vs. CORT DFP) or across challenge group (#: SL vs. LPS). Values for ( B , C ) are found in , respectively.
Article Snippet: Briefly, serum samples were analyzed using
Techniques: Expressing, Saline, Quantitative RT-PCR